Article

Proteomics of autophagy deficient macrophages reveals enhanced antimicrobial immunity via the oxidative stress response

2020-09-12

Abstract excerpt

Defective autophagy is associated with chronic inflammation. Loss-of-function of the core autophagy gene Atg16l1 increases risk for Crohn’s disease by enhancing innate immunity in macrophages. However, autophagy also mediates clearance of intracellular pathogens. These divergent observations prompted a re-evaluation of ATG16L1 in antimicrobial immunity. In this study, we found that loss of Atg16l1 in macrophages e...

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Literature Corpus work: b78f49fc-c074-5ce9-89bd-668004e8ea23
DOI: 10.1101/2020.09.10.291344

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