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Article

Autophagy in Crohn’s Disease: Converging on Dysfunctional Innate Immunity

4 Jul 2023

Abstract excerpt

Crohn’s disease (CD) is a chronic inflammatory bowel disease marked by relapsing, transmural intestinal inflammation driven by innate and adaptive immune responses. Autophagy is a multi-step process that plays a critical role in maintaining cellular homeostasis by degrading intracellular components, such as damaged organelles and invading bacteria. Dysregulation of autophagy in CD is revealed by the...

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PMID: 37443813
DOI: 10.3390/cells12131779

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