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Article

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.

Nature - 13 Nov 2008

Saitoh Tatsuya, Fujita Naonobu, Jang Myoung Ho, Uematsu Satoshi, Yang Bo-Gie, Satoh Takashi, Omori Hiroko, Noda Takeshi, Yamamoto Naoki, Komatsu Masaaki, Tanaka Keiji, Kawai Taro, Tsujimura Tohru, Takeuchi Osamu, Yoshimori Tamotsu, Akira Shizuo

Abstract excerpt

Systems for protein degradation are essential for tight control of the inflammatory immune response. Autophagy, a bulk degradation system that delivers cytoplasmic constituents into autolysosomes, controls degradation of long-lived proteins, insoluble protein aggregates and invading microbes, and...

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PMID: 18849965
DOI: 10.1038/nature07383

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18849965-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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