Article

Loss of PAX6 alters the excitatory/inhibitory neuronal ratio in human cerebral organoids

2023-08-01

Abstract excerpt

The transcription factor PAX6 is a crucial regulator of multiple aspects of embryonic forebrain development. It has well-established roles in the regulation of excitatory and inhibitory neuron development in the embryonic cortex in mice but PAX6’s roles during human forebrain development are less well understood. Using human cerebral organoids, we investigated PAX6’s roles in human neurodevelopment. Homozygous PAX...

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Literature Corpus work: b754a994-4431-547b-ba41-8c17e090ead4
DOI: 10.1101/2023.07.31.551262

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