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Article

Pax6 mutant cerebral organoids partially recapitulate phenotypes of Pax6 mutant mouse strains.

PloS one - 1 Jan 2022

Ferdaos Nurfarhana, Lowell Sally, Mason John O

Abstract excerpt

Cerebral organoids show great promise as tools to unravel the complex mechanisms by which the mammalian brain develops during embryogenesis. We generated mouse cerebral organoids harbouring constitutive or conditional mutations in Pax6, which encodes a transcription factor with multiple important roles in brain development. By comparing the phenotypes of mutant organoids with the well-described phenotypes of Pax6...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36441708
DOI: 10.1371/journal.pone.0278147
PMCID: PMC9704552

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