Article

Apically localized PANX1 impacts neuroepithelial expansion in human cerebral organoids

2023-07-29

Abstract excerpt

Dysfunctional paracrine signaling through Pannexin 1 (PANX1) channels is linked to several adult neurological pathologies and emerging evidence suggests that PANX1 plays an important role in human brain development. It remains unclear how early PANX1 influences brain development, or how loss of PANX1 alters the developing human brain. Using a cerebral organoid model of early human brain development, we find that P...

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Literature Corpus work: c9043923-b409-5ca0-80a7-61d625ebb64d
DOI: 10.1101/2023.07.28.550996

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