Article

Loss of <i>UBE3A</i> impacts both neuronal and non-neuronal cells in human cerebral organoids

2024-02-10

Abstract excerpt

Angelman syndrome is a neurodevelopmental disorder caused by (epi)genetic lesions of maternal UBE3A . Research has focused largely on the role of UBE3A in neurons due to its imprinting in that cell type. Yet, evidence suggests there may be broader neurodevelopmental impacts of UBE3A dysregulation. Human cerebral organoids might reveal these understudied aspects of UBE3A as they recapitulate diverse cell types...

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Literature Corpus work: f9aa6edb-02ae-5f53-8b19-0fc3a118db02
DOI: 10.1101/2024.02.09.579672

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