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<i>In Vitro</i> Modeling of CD8 T Cell Exhaustion Enables CRISPR Screening to Reveal a Role for BHLHE40

2023-04-19

Abstract excerpt

Identifying novel molecular mechanisms of exhausted CD8 T cells (T ex ) is a key goal of improving immunotherapy of cancer and other diseases. However, high-throughput interrogation of in vivo T ex can be costly and inefficient. In vitro models of T ex are easily customizable and quickly generate high cellular yield, offering an opportunity to perform CRISPR screening and other high-throughput assays. We esta...

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Literature Corpus work: b74d3992-57f9-545d-a674-5bfd401b7cc1
DOI: 10.1101/2023.04.17.537229

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