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Article

Dynamic chromatin regulatory landscape of human CAR T cell exhaustion

2021-04-02

Abstract excerpt

<h4>ABSTRACT</h4> Dysfunction in T cells limits the efficacy of cancer immunotherapy 1–6 . We profiled the epigenome, transcriptome, and enhancer connectome of exhaustion-prone GD2-targeting HA-28z chimeric antigen receptor (CAR) T cells and control CD19-targeting CAR T cells, which present less exhaustion-inducing tonic signaling, at multiple points during their ex vivo expansion 7 . We found widespread, dyna...

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Literature Corpus work
a34f1480-e28b-58f0-aa4f-a2b17273f524
DOI
10.1101/2021.04.02.438240
Open publication

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Dynamic chromatin regulatory landscape of human CAR T cell exhaustionDOI 10.1101/2021.04.02.438240
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