Article
Comprehensive mutational profiling and clinical outcome of adult acute myeloid leukemia patients with NUP98 rearrangement.
Leukemia - 1 Jul 2026
Ducourneau Benoit, Pages Arnaud, Struski Stéphanie, Decamp Matthieu, Raffoux Emmanuel, Berthon Céline, Fenwarth Laurène, Marmouset Vincent, Pautas Cécile, Cluzeau Thomas, Lebon Delphine, Uzunov Madalina, Pereyra Patricio, Heiblig Maël, Malfuson Jean-Valère, Farnault Laure, Dumas Pierre-Yves, Hieulle Julia, Bertoli Sarah, Chantepie Sylvain, Auger Nathalie, Bidet Audrey, Mozziconacci Marie-Joelle, Boudry Augustin, Luquet Isabelle, Chat Laureen, Loyaux Romain, El-Mur Lina, Clappier Emmanuelle, Gardin Claude, Hunault Mathilde, De Botton Stéphane, Pigneux Arnaud, Penther Dominique, Delabesse Eric, Itzykson Raphael, Preudhomme Claude, Dombret Hervé, Recher Christian, Duployez Nicolas, Micol Jean-Baptiste
Abstract excerpt
We report a large cohort of 95 adult patients with acute myeloid leukemia (AML) harboring NUP98 rearrangements (NUP98r). Patient characteristics included a young age (median 50 years [IQR 38-64]), 20% of therapy-related AML, a high WBC count (median 52×109/L), normal karyotype in 32%, FLT3-ITD in 48% and WT1 mutations in 34%. NUP98::NSD1 fusion was the most common (54%), and these patients were significantly...
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