Article

Structural probing of RNA hairpins quantifies protein occupancy on RNA and links it to function in human cells

2026-01-07

Abstract excerpt

<h4>ABSTRACT</h4> RNA structures that form inside living cells influence processes ranging from translation to RNA decay, many of which are controlled by RNA-binding proteins (RBPs). Because RBP specificity depends on both local RNA structure and sequence motifs, traditional pulldown-based methods often obscure the structural context of bound RNAs. Here, a quantitative framework based on dimethyl sulfate mutation...

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Literature Corpus work: a221d3d9-49b4-51d6-ad3b-37707b6e041d
DOI: 10.64898/2026.01.06.698062

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