Article

Decoding the Epitranscriptional Landscape from Native RNA Sequences

2018-12-17

Abstract excerpt

Sequencing of native RNA and corresponding cDNA was performed using Oxford Nanopore Technology. The % Error of Specific Bases (%ESB) was higher for native RNA than for cDNA, which enabled detection of ribonucleotide modification sites. Based on %ESB differences of the two templates, a bioinformatic tool ELIGOS was developed and applied to rRNAs of E. coli, yeast and human cells. ELIGOS captured 91%, 95%, ∼75%, re...

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Literature Corpus work: ac532d64-e01b-53bb-9287-b612805c264f
DOI: 10.1101/487819

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