Article

Single-Molecule Direct RNA Sequencing Reveals the Shaping of Epitranscriptome Across Multiple Species

2023-11-16

Abstract excerpt

N6-methyladenosine (m6A) is an essential RNA modification that regulates gene expression and influences diverse cellular processes. Yet, fully characterizing its transcriptome-wide landscape and biogenesis mechanisms remains challenging. Traditional next-generation sequencing (NGS) methods rely on short-reads aggregation, overlooking the inherent heterogeneity of RNA transcripts. Third-generation sequencing (TGS)...

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Literature Corpus work: 8815e53b-5ea6-5492-8de6-6eac2be2b1e3
DOI: 10.1101/2023.11.16.567334

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