Article

Transcriptome-wide RNA structure probing with temporal resolution

2023-09-29

Abstract excerpt

<h4>ABSTRACT</h4> Reactive small-molecule probes are widely used for RNA structure probing, however current approaches largely measure average RNA transcript dynamics and do not resolve structural differences that occur during folding or transcript maturation. Here, we present SNIPER-seq, an RNA structure probing method relying upon metabolic labeling with 2’-aminodeoxycytidine, structure-dependent 2’-amino react...

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Literature Corpus work: 478156d4-b598-5168-b30f-c01ec25e7354
DOI: 10.1101/2023.09.28.560059

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