Article

<i>In vivo</i> single-cell CRISPR uncovers distinct TNF-α programs in clonal expansion and tumorigenesis

2023-07-14

Abstract excerpt

The tumor evolution model posits that malignant transformation is preceded by randomly distributed driver mutations in cancer genes, which cause clonal expansions in phenotypically normal tissues. Although clonal expansions occur frequently in human epithelia and can remodel almost entire tissues, the mechanisms behind why only a small number of clones transform into malignant tumors remain enigmatic. Here, we dev...

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Literature Corpus work: b7358abe-9d29-567d-be0c-e8b968c35ab8
DOI: 10.1101/2023.07.13.548697

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