Article

Integrated Single-Cell and Spatial Transcriptomic Analysis Reveals an Aging-Associated Fibroblast Subtype Linked to Tumor Progression in Human Skin

2025-07-12

Abstract excerpt

<h4>ABSTRACT</h4> Aging is a major risk factor for the development of many cancers, yet the mechanisms underlying this increased susceptibility remain incompletely understood. Traditionally, the accumulation of genetic mutations over time has been considered a primary driver of age-related tumorigenesis. However, emerging evidence highlights the critical role of the aging tissue microenvironment—including changes...

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Literature Corpus work: ff15d0e1-3c8d-5f62-84de-81d31a733764
DOI: 10.1101/2025.07.09.663827

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