Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vivo single-cell CRISPR uncovers distinct TNF programmes in tumour evolution.

Nature - 1 Aug 2024

Renz Peter F, Ghoshdastider Umesh, Baghai Sain Simona, Valdivia-Francia Fabiola, Khandekar Ameya, Ormiston Mark, Bernasconi Martino, Duré Clara, Kretz Jonas A, Lee Minkyoung, Hyams Katie, Forny Merima, Pohly Marcel, Ficht Xenia, Ellis Stephanie J, Moor Andreas E, Sendoel Ataman

Abstract excerpt

The tumour evolution model posits that malignant transformation is preceded by randomly distributed driver mutations in cancer genes, which cause clonal expansions in phenotypically normal tissues. Although clonal expansions can remodel entire tissues1-3, the mechanisms that result in only a small number of clones transforming into malignant tumours remain unknown. Here we develop an in vivo single-cell CRISPR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autocrine Communication
Share to Clonal Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clone Cells

Share to Clustered Regularly Interspaced Short Palindromic Repeats

Share to Epithelial-Mesenchymal Transition

Share to Receptors, Tumor Necrosis Factor, Type I

Share to Single-Cell Analysis

Share to Tumor Necrosis Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 39020166
DOI: 10.1038/s41586-024-07663-y
PMCID: PMC11306103

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vivo single-cell CRISPR uncovers distinct TNF programmes in tumour evolution.PMID 39020166Read ↗

<i>In vivo</i> single-cell CRISPR uncovers distinct TNF-α programs in clonal expansion and tumorigenesisSemantic proximity Read ↗

An autochthonous CRISPR activation screening platform for characterizing tissue-specific oncogene selection.Semantic proximity Read ↗

Paired mutation calling and spatial transcriptomics identify cellular neighbourhoods dictating the neoplastic outcome of colitisSemantic proximity Read ↗

Joint analysis of mutational and transcriptional landscapes in human cancer reveals key perturbations during cancer evolution.Semantic proximity Read ↗

Mutations, Bottlenecks, and Clonal Sweeps: How Environmental Carcinogens and Genomic Changes Shape Clonal Evolution during Tumor Progression.Semantic proximity Read ↗

Spatially Resolved <i>in vivo</i> CRISPR Screen Sequencing via Perturb-DBiTSemantic proximity Read ↗

Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma.Semantic proximity Read ↗

Multiplexed CRISPR/Cas9 Editing of Tumor Suppressor Genes Recapitulates Molecular and Morphological Features of High-Risk Endometrial CancerSemantic proximity Read ↗

Clonal lineage tracing of innate immune cells in human cancerSemantic proximity Read ↗

Single-cell genomics analysis reveals complex genetic interactions in an in vivo model of acquired BRAF inhibitor resistance.Semantic proximity Read ↗

Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β ResistanceSemantic proximity Read ↗

In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.