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Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma

23 Jun 2020

Abstract excerpt

To define the cellular composition and architecture of cutaneous squamous cell carcinoma (cSCC), we combined single-cell RNA sequencing with spatial transcriptomics and multiplexed ion beam imaging from a series of human cSCCs and matched normal skin. cSCC exhibited four tumor subpopulations, three recapitulating normal epidermal states, and a tumor-specific keratinocyte (TSK) population unique to cancer, which...

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PMID: 32579974
DOI: 10.1016/j.cell.2020.05.039

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