Article

The effect of Wnt signaling on the localization, molecular size and activity of the beta-catenin destruction complex in vivo

2017-08-17

Abstract excerpt

Wnt signaling provides a paradigm for cell-cell signals that regulate embryonic development and stem cell homeostasis and are inappropriately activated in cancers. Our current outline of Wnt signaling focuses around several key players. The tumor suppressors APC and Axin form the core of the multiprotein destruction complex, which targets the Wnt-effector beta-catenin for phosphorylation, ubiquitination and destru...

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Literature Corpus work: b734a6d4-3cbd-5204-af64-1a2e85c8fd35
DOI: 10.1101/177790

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