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Article

Quantitative live-cell imaging and computational modeling shed new light on endogenous WNT/CTNNB1 signaling dynamics.

eLife - 30 Jun 2021

de Man Saskia Ma, Zwanenburg Gooitzen, van der Wal Tanne, Hink Mark A, van Amerongen Renée

Abstract excerpt

WNT/CTNNB1 signaling regulates tissue development and homeostasis in all multicellular animals, but the underlying molecular mechanism remains incompletely understood. Specifically, quantitative insight into endogenous protein behavior is missing. Here, we combine CRISPR/Cas9-mediated genome editing and quantitative live-cell microscopy to measure the dynamics, diffusion characteristics and absolute...

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Identifiers

PMID: 34190040
DOI: 10.7554/eLife.66440
PMCID: PMC8341982

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