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Single molecule footprinting measures low nucleosome occupancy in mature spermatozoa of mice and men

2026-07-01

Abstract excerpt

Nucleosomes are fundamental units of DNA packaging and gene regulation in eukaryotes. In mammalian sperm, most nucleosomes are replaced by protamines causing extreme chromatin compaction. Various epigenomic studies reported conflicting results on the distribution of residual nucleosomes in mammalian sperm 1–9 , questioning their potential role in mediating intergenerational inheritance of paternal epigenetic info...

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Literature Corpus work
b732744f-eafd-5665-a050-4003adee3b1a
DOI
10.64898/2026.06.30.735528
Open publication

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Single molecule footprinting measures low nucleosome occupancy in mature spermatozoa of mice and menDOI 10.64898/2026.06.30.735528
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