Article
Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules.
Genome research - 1 Dec 2012
Kelly Theresa K, Liu Yaping, Lay Fides D, Liang Gangning, Berman Benjamin P, Jones Peter A
Abstract excerpt
DNA methylation and nucleosome positioning work together to generate chromatin structures that regulate gene expression. Nucleosomes are typically mapped using nuclease digestion requiring significant amounts of material and varying enzyme concentrations. We have developed a method (NOMe-seq) tha...
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