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Article

TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction

2021-07-23

Abstract excerpt

Interferons play a critical role in regulating host immune responses to SARS-CoV-2, but the interferon (IFN)-stimulated gene (ISG) effectors that inhibit SARS-CoV-2 are not well characterized. The IFN-inducible short isoform of human nuclear receptor coactivator 7 (NCOA7) inhibits endocytic virus entry, interacts with the vacuolar ATPase, and promotes endo-lysosomal vesicle acidification and lysosomal protease act...

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Identifiers and source

Literature Corpus work
b725fe2b-021f-5ab6-8459-d4116b861d51
DOI
10.1101/2021.07.23.453488
Open publication

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TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restrictionDOI 10.1101/2021.07.23.453488
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