Back to search

Article

Functional Landscape of SARS-CoV-2 Cellular Restriction

2020-09-30

Abstract excerpt

<h4>SUMMARY</h4> A deficient interferon response to SARS-CoV-2 infection has been implicated as a determinant of severe COVID-19. To identify the molecular effectors that govern interferon control of SARS-CoV-2 infection, we conducted a large-scale gain-of-function analysis that evaluated the impact of human interferon stimulated genes (ISGs) on viral replication. A limited subset of ISGs were found to control vi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0d4d3301-452c-5747-a87a-04c731588285
DOI
10.1101/2020.09.29.319566
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Functional Landscape of SARS-CoV-2 Cellular RestrictionDOI 10.1101/2020.09.29.319566
Functional Landscape of SARS-CoV-2 Cellular RestrictionSemantic proximity
Interactome profiling reveals interaction of SARS-CoV-2 NSP13 with host factor STAT1 to suppress interferon signalingSemantic proximity
Multiple layers of innate immune response antagonism of SARS-CoV-2Semantic proximity
Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilitiesSemantic proximity
The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translationSemantic proximity
SARS-CoV-2 Nsp14 mediates the effects of viral infection on the host cell transcriptomeSemantic proximity
Redundant and distinct mechanisms suppress innate immune activation during SARS-CoV-2 infection.Semantic proximity
SARS-CoV-2 Nsp2 reprograms host immunity to drive pathogenic inflammationSemantic proximity
Ribosome-profiling reveals restricted post transcriptional expression of antiviral cytokines and transcription factors during SARS-CoV-2 infectionSemantic proximity
Host transcriptional response to SARS-CoV-2 infection in COVID-19 patientsSemantic proximity
Interferon antagonists encoded by SARS-CoV-2 at a glanceSemantic proximity
The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translationSemantic proximity
Select a neighboring publication to make it the new centre.