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Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell Signaling

25 Jul 2022

Abstract excerpt

The results of this study demonstrate that the late lineages of SARS-CoV-2 evolved to more efficient use of the TMPRSS2-mediated entry pathway and gradually lost an ability to employ the cathepsins/endosome-mediated entry. The acquisition of a furin cleavage site (FCS) by SARS-CoV-2-specific S protein made the virus a potent producer of syncytia. Their formation is also determined by expression of ACE2 and...

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PMID: 35876526
DOI: 10.1128/jvi.00753-22

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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