Article

Tetherin restricts SARS-CoV-2 replication despite antagonistic effects of Spike and ORF7a

2023-08-03

Abstract excerpt

<h4>ABSTRACT</h4> SARS-CoV-2 infection induces interferon-stimulated genes, one of which encodes Tetherin, a transmembrane protein inhibiting the release of various enveloped viruses from infected cells. Previous studies revealed that SARS-CoV encodes two Tetherin antagonists: the Spike protein (S) inducing lysosomal degradation of Tetherin, and ORF7a altering its glycosylation. SARS-CoV-2 ORF7a has also been sho...

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Literature Corpus work: 71d02628-c961-57a3-9fca-b4ed4608bf79
DOI: 10.1101/2023.07.28.550997

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