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Article

Functional Landscape of SARS-CoV-2 Cellular Restriction

2020-10-13

Abstract excerpt

A deficient interferon response to SARS-CoV-2 infection has been implicated as a determinant of severe COVID-19. To identify the molecular effectors that govern interferon control of SARS-CoV-2 infection, we conducted a large-scale gain-of-function analysis that evaluated the impact of human interferon stimulated genes (ISGs) on viral replication. A limited subset of ISGs were found to control viral infection, inc...

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Literature Corpus work
444e697b-1f1f-5179-8a85-c90f8056583e
DOI
10.2139/ssrn.3698891
Open publication

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Functional Landscape of SARS-CoV-2 Cellular RestrictionDOI 10.2139/ssrn.3698891
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