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Article

TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction

22 Nov 2021

Abstract excerpt

Interferons play a critical role in regulating host immune responses to SARS-CoV-2, but the interferon (IFN)-stimulated gene (ISG) effectors that inhibit SARS-CoV-2 are not well characterized. The IFN-inducible short isoform of human nuclear receptor coactivator 7 (NCOA7) inhibits endocytic virus entry, interacts with the vacuolar ATPase, and promotes endo-lysosomal vesicle acidification and lysosomal protease...

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PMID: 34807954
DOI: 10.1371/journal.ppat.1009820

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