Article

A multi-omics genome-and-transcriptome single-cell atlas of human preimplantation embryogenesis reveals the cellular and molecular impact of chromosome instability

2023-03-10

Abstract excerpt

<h4>ABSTRACT</h4> The frequent acquisition of genomic abnormalities in human preimplantation embryos is a leading cause of pregnancy loss, but does not necessarily prohibit healthy offspring. However, the impact of genomic abnormalities on cellular states and development of the early human embryo remains largely unclear. Here, we characterise aneuploidy and reconstruct gene regulatory networks in human preimplant...

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Literature Corpus work: b714552d-803c-5023-9246-26a212dac1d6
DOI: 10.1101/2023.03.08.530586

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