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Article

Single-cell analysis of human embryos reveals diverse patterns of aneuploidy and mosaicism.

Genome research - 1 Jun 2020

Starostik Margaret R, Sosina Olukayode A, McCoy Rajiv C

Abstract excerpt

Less than half of human zygotes survive to birth, primarily due to aneuploidies of meiotic or mitotic origin. Mitotic errors generate chromosomal mosaicism, defined by multiple cell lineages with distinct chromosome complements. The incidence and impacts of mosaicism in human embryos remain controversial, with most previous studies based on bulk DNA assays or comparisons of multiple biopsies of few embryonic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32641298
DOI: 10.1101/gr.262774.120
PMCID: PMC7370883

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