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Mosaic results after preimplantation genetic testing for aneuploidy may be accompanied by changes in global gene expression

14 Apr 2023

Abstract excerpt

Aneuploidy in preimplantation embryos is a major cause of human reproductive failure. Unlike uniformly aneuploid embryos, embryos diagnosed as diploid-aneuploid mosaics after preimplantation genetic testing for aneuploidy (PGT-A) can develop into healthy infants. However, the reason why these embryos achieve full reproductive competence needs further research. Current RNA sequencing techniques allow for the...

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PMID: 37122560
DOI: 10.3389/fmolb.2023.1180689

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