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Dissecting the molecular features of bovine-arrested eight-cell embryos using single-cell multi-omics sequencing

24 Mar 2023

Abstract excerpt

The regulation of mammalian early-embryonic development is a complex, coordinated process that involves widespread transcriptomic and epigenetic remodeling. The main cause of developmental failure in preimplantation embryos after in vitro fertilization is the irreversible arrested-at-cleavage stage. To deepen our understanding of this embryonic block, we profiled a single-cell multi-omics map of copy number...

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Share to Chromosomal and Genetic Variations
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PMID: 36961504
DOI: 10.1093/biolre/ioad038

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