Article

Single-cell analysis of human embryos reveals diverse patterns of aneuploidy and mosaicism

2020-01-07

Abstract excerpt

Less than half of human zygotes survive to live birth, primarily due to aneuploidies of meiotic or mitotic origin. Mitotic errors lead to chromosomal mosaicism, defined by multiple cell lineages with distinct chromosome complements. The incidence and fitness consequences of chromosomal mosaicism in human embryos remain controversial, with most previous studies based on bulk DNA assays or comparisons of multiple bi...

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Literature Corpus work: 762b851c-1c6b-5ebd-8372-dbdeac820ac8
DOI: 10.1101/2020.01.06.894287

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