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Genome‐wide abnormalities in embryos: Origins and clinical consequences

15 Jan 2021

Abstract excerpt

Ploidy or genome-wide chromosomal anomalies such as triploidy, diploid/triploid mixoploidy, chimerism, and genome-wide uniparental disomy are the cause of molar pregnancies, embryonic lethality, and developmental disorders. While triploidy and genome-wide uniparental disomy can be ascribed to fertilization or meiotic errors, the mechanisms causing mixoploidy and chimerism remain shrouded in mystery. Different...

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PMID: 33524193
DOI: 10.1002/pd.5895

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