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Single-cell DNA sequencing reveals a high incidence of chromosomal abnormalities in human blastocysts

4 Jan 2024

Abstract excerpt

Aneuploidy, a deviation from the normal chromosome copy number, is common in human embryos and is considered a primary cause of implantation failure and early pregnancy loss. Meiotic errors lead to uniformly abnormal karyotypes, while mitotic errors lead to chromosomal mosaicism: the presence of cells with at least 2 different karyotypes within an embryo. Knowledge about mosaicism in blastocysts mainly derives...

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PMID: 38175717
DOI: 10.1172/jci174483

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