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CASM regulates p62/KEAP1/NRF2 antioxidant responses to lysosome damage

2026-07-08

Abstract excerpt

Effective lysosome function is essential for health, and declines with ageing and disease. Upon lysosome damage, cells mount a complex stress response to restore homeostasis. Membrane ATG8ylation plays a central role, orchestrating lysosome repair, replacement and removal, either directly at the damaged membrane, via CASM ( c onjugation of A TG8s to s ingle m embranes), or at nascent autophagosomes, during lys...

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Literature Corpus work
b706d82e-1654-5504-a28a-7775bb036754
DOI
10.64898/2026.07.08.736046
Open publication

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CASM regulates p62/KEAP1/NRF2 antioxidant responses to lysosome damageDOI 10.64898/2026.07.08.736046
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