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p62/SQSTM1 – steering the cell through health and disease

1 Nov 2018

Abstract excerpt

SQSTM1 (also known as p62) is a multifunctional stress-inducible scaffold protein involved in diverse cellular processes. Its functions are tightly regulated through an extensive pattern of post-translational modifications, and include the isolation of cargos degraded by autophagy, induction of the antioxidant response by the Keap1-Nrf2 system, as well as the regulation of endosomal trafficking, apoptosis and...

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PMID: 30397181
DOI: 10.1242/jcs.222836

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