Back to search

Article

Serine ubiquitination of p62 regulates Nrf2 dependent redox homeostasis

2023-06-18

Abstract excerpt

The KEAP1–Nrf2 axis is essential for the cellular response against metabolic and oxidative stress. KEAP1 is an adaptor protein of Cullin-3 ubiquitin ligase that controls the cellular levels of Nrf2, a critical transcription factor of several cytoprotective genes. Oxidative stress, defective autophagy and pathogenic infections activate Nrf2 signaling through phosphorylation of the adaptor protein p62, which compete...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
61812571-b8cd-54e3-845d-ba0e073d9d84
DOI
10.1101/2023.06.17.545420
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Serine ubiquitination of p62 regulates Nrf2 dependent redox homeostasisDOI 10.1101/2023.06.17.545420
The Molecular Mechanisms Regulating the KEAP1-NRF2 PathwaySemantic proximity
The Pathways Underlying the Multiple Roles of p62 in Inflammation and CancerSemantic proximity
Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosisSemantic proximity
Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosisSemantic proximity
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.Semantic proximity
p62-Nrf2-p62 Mitophagy Regulatory Loop as a Target for Preventive Therapy of Neurodegenerative DiseasesSemantic proximity
Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosisSemantic proximity
p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene TranscriptionSemantic proximity
CASM regulates p62/KEAP1/NRF2 antioxidant responses to lysosome damageSemantic proximity
Ubiquitin and Legionella: From bench to bedsideSemantic proximity
The role of ubiquitination in microbial infection induced endothelial dysfunction: potential therapeutic targets for sepsisSemantic proximity
The Ubiquitination System within Bacterial Host–Pathogen InteractionsSemantic proximity
Select a neighboring publication to make it the new centre.