Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p62 at the Interface of Autophagy, Oxidative Stress Signaling, and Cancer

10 Nov 2011

Abstract excerpt

SIGNIFICANCE: Sequestosome 1 (p62/SQSTM1) is a multifunctional adapter protein implicated in selective autophagy, cell signaling pathways, and tumorigenesis. RECENT ADVANCES: Recent evidence has revealed that p62/SQSTM1 has a critical role in an oxidative stress response pathway by its direct interaction with the ubiquitin ligase adaptor Kelch-like ECH-associated protein 1 (KEAP1), which results in constitutive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cancer-related Molecular Pathways
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22074114
DOI: 10.1089/ars.2011.4394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p62 at the Interface of Autophagy, Oxidative Stress Signaling, and CancerPMID 22074114Read ↗

Activation of p62/SQSTM1–Keap1–Nuclear Factor Erythroid 2-Related Factor 2 Pathway in CancerSemantic proximity Read ↗

p62/SQSTM1 in cancer: phenomena, mechanisms, and regulation in DNA damage repairSemantic proximity Read ↗

p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene TranscriptionSemantic proximity Read ↗

p62/SQSTM1 – steering the cell through health and diseaseSemantic proximity Read ↗

The Pathways Underlying the Multiple Roles of p62 in Inflammation and CancerSemantic proximity Read ↗

p62-Nrf2-p62 Mitophagy Regulatory Loop as a Target for Preventive Therapy of Neurodegenerative DiseasesSemantic proximity Read ↗

p62/SQSTM1 at the interface of aging, autophagy, and diseaseSemantic proximity Read ↗

p62: Friend or Foe? Evidences for OncoJanus and NeuroJanus RolesSemantic proximity Read ↗

CASM regulates p62/KEAP1/NRF2 antioxidant responses to lysosome damageSemantic proximity Read ↗

The Multifunctional Protein p62 and Its Mechanistic Roles in CancersSemantic proximity Read ↗

Autophagic Regulation of p62 is Critical for Cancer TherapySemantic proximity Read ↗

Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.