Article

Differential regulation of p62-ubiquitin conjugates in neurons versus astrocytes during cellular stress

2025-11-18

Abstract excerpt

<h4>ABSTRACT</h4> Sequestosome 1/p62 (hereafter referred to as p62) is a multifunctional protein that orchestrates various cellular stress response pathways including autophagy, proteasome-mediated degradation, antioxidant defense, nutrient sensing, and inflammatory signaling. Mutations in distinct functional domains of p62 are linked with the neurodegenerative disease amyotrophic lateral sclerosis (ALS), undersc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d26e9907-4778-5557-bc81-9b1156b78186
DOI: 10.1101/2025.11.17.688722

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Differential regulation of p62-ubiquitin conjugates in neurons versus astrocytes during cellular stressDOI 10.1101/2025.11.17.688722Read

The converging roles of sequestosome-1/p62 in the molecular pathways of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)Semantic proximity Read

Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and AgingSemantic proximity Read

Molecular mechanisms underlying p62-dependent secretion of the Alzheimer-associated ubiquitin variant, UBB <sup>+1</sup>Semantic proximity Read

Ubiquitination at the mitochondria in neuronal health and diseaseSemantic proximity Read

p62: Friend or Foe? Evidences for OncoJanus and NeuroJanus RolesSemantic proximity Read

Ubr1-induced selective endo-phagy/autophagy protects against the endosomal and Ca <sup>2+</sup> -induced proteostasis disease stressSemantic proximity Read

Review: Autophagy and neurodegeneration: survival at a cost?Semantic proximity Read

New molecular signatures defining the differential proteostasis response in ALS-resistant and -sensitive motor neuronsSemantic proximity Read

Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunitiesSemantic proximity Read

Proteostasis dysregulation in p.A53T-α-Synuclein iPSC-derived astrocytes exacerbates neurodegeneration in a Parkinson’s disease model with Lewy-like pathologySemantic proximity Read

Small heterodimer partner (SHP) aggravates ER stress in Parkinson's disease-linked LRRK2 mutant astrocyte by regulating XBP1 SUMOylation.Semantic proximity Read

NFE2L1 as a central regulator of proteostasis in neurodegenerative diseases: interplay with autophagy, ferroptosis, and the proteasomeSemantic proximity Read