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p62/SQSTM1 in cancer: phenomena, mechanisms, and regulation in DNA damage repair

15 Feb 2025

Abstract excerpt

The multidomain protein cargo adaptor p62, also known as sequestosome 1, serves as a shuttling factor and adaptor for the degradation of substrates via the proteasome and autophagy pathways. Regarding its structure, p62 is composed of several functional domains, including the N-terminal Phox1 and Bem1p domains, a ZZ-type zinc finger domain, a LIM protein-binding domain that contains the tumor necrosis factor...

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PMID: 39954143
DOI: 10.1007/s10555-025-10250-w

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