Article
Repeat-associated non-ATG (RAN) translation in neurological disease.
Human molecular genetics - 15 Oct 2013
Cleary John D, Ranum Laura P W
Abstract excerpt
Well-established rules of translational initiation have been used as a cornerstone in molecular biology to understand gene expression and to frame fundamental questions on what proteins a cell synthesizes, how proteins work and to predict the consequences of mutations. For a group of neurological diseases caused by the abnormal expansion of short segments of DNA (e.g. CAG•CTG repeats), mutations within or outside...
Topics
- C9orf72 Protein
- Codon, Initiator
- Fragile X Mental Retardation Protein
- Gene Expression
- Mutant Proteins
- Mutation
- Myotonin-Protein Kinase
- Nerve Tissue Proteins
- Nervous System Diseases
- Open Reading Frames
- Peptide Chain Initiation, Translational