Article

Comparative analysis of RAN translation from CAG repeats within the Huntingtin coding sequence

2025-09-04

Abstract excerpt

Repeat associated non-AUG (RAN) translation is a non-canonical initiation event that occurs in the absence of a start codon in repeat expansion disorders, generating aggregation-prone proteins which may contribute to pathogenicity. The mechanism by which repeats trigger RAN translation is not completely understood, with most prior work focused on how repeats might elicit initiation when placed within a 5’ leader i...

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Literature Corpus work: 3c714e3b-afd9-5f62-a82e-98b97b6b7455
DOI: 10.1101/2025.09.02.673827

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