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Article

Repeat-Associated Non-ATG Translation in Neurological Diseases.

Cold Spring Harbor perspectives in biology - 3 Dec 2018

Zu Tao, Pattamatta Amrutha, Ranum Laura P W

Abstract excerpt

More than 40 different neurological diseases are caused by microsatellite repeat expansions that locate within translated or untranslated gene regions, including 5' and 3' untranslated regions (UTRs), introns, and protein-coding regions. Expansion mutations are transcribed bidirectionally and have been shown to give rise to proteins, which are synthesized from three reading frames in the absence of an AUG...

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Identifiers

PMID: 29891563
DOI: 10.1101/cshperspect.a033019
PMCID: PMC6280704

Genes

RAN

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