Article

PRMT5 is required for full-length <i>HTT</i> expression by repressing multiple proximal intronic polyadenylation sites

2024-03-14

Abstract excerpt

Expansion of the CAG trinucleotide repeat tract in exon 1 of the Huntingtin ( HTT ) gene above a threshold of ∼36 repeats causes Huntington’s disease (HD) through the expression of a polyglutamine-expanded form of the HTT protein. This mutation triggers wide-ranging cellular and biochemical pathologies leading to cognitive, motor, and psychiatric symptoms in HD patients. As accurate splicing is required to produ...

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Literature Corpus work: f6d18328-1c42-5199-940f-13feadc4ff69
DOI: 10.1101/2024.03.14.584861

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