Article

Defective linear and circular RNAs biogenesis in Huntington’s disease: CAG repeat expansion hijacks neuronal splicing

2021-12-27

Abstract excerpt

<h4>ABSTRACT</h4> Alternative splicing (AS) appears to be altered in Huntington’s disease (HD), but its significance for early, pre-symptomatic disease stages has not been inspected. Here, taking advantage of Htt CAG knock-in mouse in vitro and in vivo models, we demonstrate a strong correlation between Htt CAG repeat length and increased aberrant linear AS, specifically affecting neural progenitors and, in...

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Literature Corpus work: 7c886b6d-7e13-5950-ab90-45f342dfe207
DOI: 10.1101/2021.12.27.474266

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