Article
Normal and expanded Huntington's disease gene alleles produce distinguishable proteins due to translation across the CAG repeat.
Molecular medicine (Cambridge, Mass.) - 1 May 1995
Persichetti F, Ambrose C M, Ge P, McNeil S M, Srinidhi J, Anderson M A, Jenkins B, Barnes G T, Duyao M P, Kanaley L
Abstract excerpt
BACKGROUND: An expanded CAG trinucleotide repeat is the genetic trigger of neuronal degeneration in Huntington's disease (HD), but its mode of action has yet to be discovered. The sequence of the HD gene places the CAG repeat near the 5' end in a region where it may be translated as a variable polyglutamine segment in the protein product, huntingtin. MATERIALS AND METHODS: Antisera directed at amino acid...
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