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Lithium partially rescues gene expression and enhancer activity from heterozygous knockout of <i>AKAP11</i> while inducing novel differential changes

2025-02-28

Abstract excerpt

Bipolar disorder (BD) is a complex psychiatric condition usually requiring long-term treatment. Lithium (Li) remains the most effective mood stabilizer for BD, yet it benefits only a subset of patients, and its precise mechanism of action remains elusive. Exome sequencing has identified AKAP11 (A-kinase anchoring protein 11) as a shared risk gene for BD and schizophrenia (SCZ). Given that both the AKAP11-Protein...

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Literature Corpus work
b6c8df82-dddd-5055-b2a1-8a8cdbee6659
DOI
10.1101/2025.02.24.639480
Open publication

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