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Article

Lithium-related genetics of bipolar disorder

1 Jan 2001

Abstract excerpt

Lithium is a potent prophylactic medication and mood stabilizer in bipolar disorder. However, clinical outcome is variable, and its therapeutic effect manifests after a period of chronic treatment, implying a progressive and complex biological response process. Signal transduction systems known to be perturbed by lithium involve phosphoinositide (PI) turnover, activation of the Wnt pathway via inhibition of...

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PMID: 11405549
DOI: 10.3109/07853890108998756

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