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Lithium response in bipolar disorder: Epigenome-wide DNA methylation signatures and epigenetic aging

25 Apr 2024

Abstract excerpt

Lithium (Li) is the first-line treatment for bipolar disorder (BD) even though only 30 % of BD patients are considered excellent responders. The mechanisms by which Li exerts its action are not clearly understood, but it has been suggested that specific epigenetic mechanisms, such as methylation processes, may play a role. In this regard, DNA methylation patterns can be used to estimate epigenetic age (EpiAge),...

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PMID: 38669938
DOI: 10.1016/j.euroneuro.2024.03.010

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